By Mamta Singh
Here is one more reason why you should put on that workout gear and exercise. To the already long list of benefits that can be availed from following a regular workout routine, a new study conducted by the researchers at McMaster University, Canada now adds another benefit. And this benefit may be had even if you exercise only moderately every other day of the week.
It seems that the body’s influential stem cells are urged, during an exercise session, to develop into a bone cell rather than a fat cell. (1)
In other words, the benefit also doubles up as the reason why people who work out have better bone density and are fitter instead of flabby or with low bone mass.
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Advances in the study of stem cells have fueled hopes that someday, via regenerative medicine, doctors could restore aging people’s hearts, livers, brains and other organs and tissues to a more youthful state. A key to reaching this goal — to be able to provide stem cells that will differentiate into other types of cells a patient needs — appears to lie in understanding “epigenetics,” which involves chemical marks stapled onto DNA and its surrounding protein husk by specialized enzyme complexes inside a cell’s nucleus. These markings produce long-lasting changes in genes’ activity levels within the cell — locking genes into an “on” or “off” position. Epigenetic processes enable cells to remain true to type (a neuron, for instance, never suddenly morphs into a fat cell) even though all our cells, regardless of type, share the same genetic code. But epigenetic processes also appear to play a critical role in reducing cells’ vitality as they age.
Bruce Goldman of the Office of Communication & Public Affairs recently talked to Thomas Rando, MD, PhD, professor of neurology and neurological sciences and director of the Glenn Laboratories for the Biology of Aging at Stanford, about the prospects for rejuvenating tissues by reprogramming the epigenetic settings of stem cells within those tissues. Rando and Howard Chang, MD, PhD, professor of dermatology, are co-authors of a review article on this subject published Jan. 20 in Cell.
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China’s instant ban on unapproved stem cell treatment will affect some US patients, and a handful of specialist medical tourism agencies who have been accessing China for treatment that is not available in the US or most European countries.
In recent years, China has attracted foreign citizens to experimental hospitals and doctors willing to treat seriously ill patients with unproven stem-cell therapies.
The Ministry of Health announced that the country has stopped all unproven and experimental stem-cell treatment programmes and refuses to accept any new applications for approval of stem-cell treatments. The ban will initially last until the end of June 2012, but the chances of the ban being lifted quickly after then seem very slim.
China’s experimental stem-cell treatments have been used on patients with severe neurological diseases, other chronic illnesses and injuries. While some patients have said that these unproven stem cell therapy programs in China have done them good, critics argue that the benefit is purely in the mind.
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New research by scientists in the United States has claimed that using stem cells from cord blood could help to reverse type 1 diabetes. It has been shown to re-educate the immune system T cells of patients so that their pancreas begins to produce insulin again, so that the amount of insulin they need to inject to deal with their condition is lessened.
Cord blood, taken from the placenta and umbilical cord post-childbirth, has become an increasing source of stem cells for treating a variety of blood and genetic disorders. Cells from cord blood have already been shown to manage autoimmune responses by changing regulatory T cells and human islet beta cell-specific T cell clones in laboratory experiments.
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BEIJING – China’s top health authority will strictly regulate the cutting-edge stem cell treatment, which attracts thousands of patients from abroad each year, to ensure patient safety and the orderly development of the technology.
A one-year overhaul highlighting self-examination among practitioners will be launched to detect and eliminate irregularities surrounding the issue, said Deng Haihua, spokesman of the Ministry of Health at a news conference on Tuesday.
“All medical research and clinical practices of stem cell therapy without approval from the ministry and the State Food and Drug Administration will be put to an end after the overhaul,” he told China Daily.
Largely due to concerns over ethics, treatment efficacy, and a lack of relative laws and regulations, the health authority has never approved clinical use of the therapy on the mainland, Deng stressed.
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Sarah Knauss, famous for being among the oldest people in the world until her death at the age of 119, might have had more than just “good genes.” Dana-Farber’s Wayne Marasco, MD, PhD, says that adult stem cells – known for their healing and regenerative properties – might hold the key to a long and healthy life.
Marasco shared his expertise on the subject at the recent International Vatican Conference on Adult Stem Cells in Vatican City, Italy, an event attended by a select group of cardinals, clergy, and leading researchers and physicians from around the world.
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Pro-lifers and Gov. Scott Walker say they’re a better way to go. Scientists beg to differ
By Nathan J. Comp
Saul Richman’s prospects were not good. In November 2009, after what he thought was the flu turned out to be leukemia, he underwent a week of 24-hour chemo. When that didn’t work, more chemo sent the cancer into remission, but with an 80% chance that it would return. Richman needed a bone-marrow transplant and, even then, his prospects were grim.
“Once you have leukemia, it’s already kind of too late,” says Karen, Saul’s wife of 41 years.
In May, an international donor search failed to find a match. The Richmans’ time and options were running out. Then something unexpected happened.
“We were referred to UW,” Karen recalls. “They said, ‘There’s one more thing we’ve been having good results with.’ We thought we were going there for a bone-marrow transplant, but they said, ‘No, this is something completely different.’”
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For a long time many of us in the stem cell field have been worried about dubious stem cell treatments, so-called ‘stem cell tourism’.
How do we stop it or at least fight back to keep people safe and help them avoid losing what is often their life savings?
Many activities related to stem cell tourism occur right here in the U.S. and almost entirely or entirely involve adult stem cells. Interestingly it is often the folks who are most opposed to embryonic stem cell research who promote expensive, untested and potentially dangerous adult stem cell research therapies. While they oppose embryonic stem cell research claiming it involves the lose of a “life” in the form of a few cell embryo, the adult stem cell research they push will inevitably kill an actual living, breathing person.
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By Jim Forsyth
(Reuters) – Three men were arrested and a fourth is being sought by the FBI in what investigators said was a scheme to market stem cells as miracle cures to desperate people suffering from terminal diseases.
The arrests began in the past 10 days after two indictments were issued in November charging the four with 39 counts of mail fraud and unlawfully manufacturing, distributing and selling stem cells and stem cell procedures not approved by the Food and Drug Administration.
The FBI said the men received more than $1.5 million from patients suffering from incurable diseases.
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When stroke patients do not receive immediate care the chances of suffering paralysis, disturbances to speech and impaired vision increase. A new stem cell therapy aims to reverse the effects a stroke has on the body.
At first glance, the sheep in the compound of Leipzig’s faculty of veterinary medicine look like your ordinary sheep. But if you take a closer look, you see that parts of them have been sheared.
“We took cells from iliac crest and we can’t run the risk of contamination,” explained Johannes Boltze, head of the Department of Cell Therapy at Fraunhofer Institute for Cell Therapy and Immunology in Leipzig.
The sheep’s bone marrow contains stem cells that can transform into a variety of types of cells and which form the basis for the new therapy researchers are putting to the test.
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